PCRF has a long history of supporting cutting-edge pediatric cancer research 

The Pediatric Cancer Research Foundation identifies and invests in leading edge research that demonstrates the best hope for a cure to childhood cancer. PCRF invites you to walk with us as we vigorously pursue eliminating childhood cancer through research.

Our values inspire us to make a difference: Knowledge, Caring, Hope, Forward Thinking. We salute the tireless dedication and contributions of our staff, researchers, partners and volunteers. Through their work and commitment, PCRF has become a respected international organization – raising over $48 million dollars for pediatric cancer research. The lives of many children and their families have been profoundly impacted by this research and we encourage you to read some of their inspiring stories.

Since 1982, we’ve made huge strides in the treatment, care, and prevention of childhood cancers. However, as we look back and celebrate our progress, we also look forward – knowing there is more work to be done. PCRF is a pioneer in eliminating childhood cancer through our ability to identify and fund cutting edge research. We exclusively target funds toward emerging and breakthrough opportunities.

Decades of Progress, Success, Hope

What We Know About Childhood Cancer

Pediatric cancer is a growing problem worldwide. A child or adolescent is diagnosed with cancer every two minutes. In the United States, cancer is the leading cause of death by disease in children past infancy. The facts and information available challenge everyone to become involved with PCRF’s mission to identify and invest in leading edge research that demonstrates the best hope for a cure of childhood cancer. Share this information with others and encourage them to join the fight.

Children 0-14 years diagnosed with cancer in the U.S. each year
Adolescents age 15-19 diagnosed with cancer in the U.S. each year
Youth under 19 diagnosed with cancer each year worldwide
Survivors of childhood cancer alive in the U.S. as of 2020

What PCRF has Accomplished

raised for Pediatric Cancer Research
Active Grants for Pediatric Cancer Research
+ Research Institutions Funded

Your Gift Powers HOPE

An average of 43 children and adolescents are diagnosed with cancer every day in the United States (almost 16,000 annually) and that number is dramatically compounded when we look worldwide: nearly 250,000 new cases of cancer affect children annually, or 700 new children affected every day around the globe (The Lancet Oncology. 2013; 14(3): e95-e103). As evidenced by these numbers, pediatric cancer is not rare – in fact, it remains the number one disease killer of all children. More children die from cancer than pediatric AIDS, asthma, diabetes, cystic fibrosis and congenital anomalies combined (http://www.cancer.gov/cancertopics/factsheet/Sites-Types/childhood). Time will not stand still as we search for a cure, which means we must work quickly, strategically, diligently, and in collaboration to combat childhood cancer. We thank you in advance for your partnership and contribution that helps give hope to children and families.

How Your Support Powers Results

Founded in 1982 by physicians, parents and community leaders, Pediatric Cancer Research Foundation (PCRF) has raised over $51 Million for cancer research since its inception. This represents the persistent hard work of physicians, researchers, volunteers, staff and community partners who are dedicated to the health of our future generation—our children. Our mission has stayed true over the course of time: to identify and invest in leading edge research that demonstrates the best hope for a cure of childhood cancer. Over the last 40 years, we have seen drastic improvements – overall survival rates for childhood cancer have risen from 10% to almost 85%. Because of research, the cancer death rate has dropped more dramatically for children than for any other age group. However, there are still childhood cancers that have not had the same results – rare and aggressive cancers continue to devastate families and rob children of their childhoods.

Because childhood cancers still exist, PCRF presses on, funding experienced and emerging researchers to continue the necessary work of finding cures and improvements in care. Your partnership with PCRF powers this gift of Hope. Hope for a cure, hope for aggressive treatments that attack cancer cells but leave the healthy cells, hope for long-term quality of life through safer therapies to fight cancer. Hope for new research, new protocols, new interventions.

Throughout our history of supporting pediatric cancers, we have maintained a stable foundation financially. This year we attained a Platinum rating from GuideStar. What this means for our donors is that you can have confidence in PCRF’s ability to fund the best researchers in the world, with the utmost attention to financial efficacy and transparency.

The Pediatric Cancer Research Foundation has been sustained for the last 40 years thanks to the caring investment of individuals, organizations, and business like you! Your trust over the years is truly valued and put to excellent use in advancing effective life-saving treatments for children diagnosed with malignant disease.

PCRF is located in Irvine, California, and currently funds 13 institutions across the country. Cancer knows no boundaries, and neither do we. We will stand vigil until a cure is found.

The People that Make it Happen


Children make up 10% of our cancer population, but they are 100% of our future! ~ Dr. Alex Huang, Case Western