b'DEAR FRIENDS,From the beginning, our purpose has been to power the discovery of safer and better cures, enabling all children and their families to beat pediatric cancers and live happy, healthy, productive lives after treatment. Thanks to the initiative of researchers and our incredible community of generous donors, the field has come a long way. With your help, our funding is pioneering the advancement of early-stage research into life-changing innovations. Overall survival rates have improved significantly and we can now point to breakthroughs in some of the least understood and most difficult-to-treat childhood cancers.Despite these notable achievements, of which we all can be proud, we have more to do. There is a clear need to continue the hard work of funding high-potential researchand to increase the number of grants being awarded. Our focus is on accelerating the pace of scientific discovery and increasing the likelihood of translating insights into better care for our children and their families, sooner.Our aspiration is to expand our impact by raising more funding to grant innovative research. We share this commitment with our researchers at cutting-edge institutional partners nationwide, all working together to discover and advance better care for all pediatric patients. We are united by one collective goalto beat pediatric cancers.This work is far too important to give it anything less than everything we have and we cannot do it alone. With our efforts and your generosity, we will have more achievements and milestones to celebrate in the year ahead. Together, we can develop better cures for childhood cancers in our lifetime.For the children,Danielle Fragalla, MSEChief Executive Officer5'