The Pediatric Cancer Research Foundation (PCRF) has raised over $51 Million for cancer research since 1982. Through this and other efforts in the childhood cancer community, we have witnessed pediatric cancer survival rates rise from 10% to nearly 85%. This is outstanding progress and an important testament to how vital cancer research is. But there is still a lot of work to do and we look forward to seeing even greater strides made in the coming years as people like you come together with organizations like ours to help change the landscape of childhood cancer.
For more information and procedures, please see the Grants tab. The Foundation currently funds grants for research in the following areas:
Molecular and Cellular Genetics
The understanding of molecular and cellular genetices in childhood cancer is crucial. This research focuses on investigations into the mechanisms and new experimental approaches to control and turn off cancer-causing genes (oncogenes) and the insertion of new genes (gene therapy) to enhance immune-mediated tumor killing and correction of genetic defects.
Stem Cell Biology
Stem cell research has been instrumental in advancing cancer treatment. Research studies include investigations in the molecular and cellular regulation of blood cell formation, enhancement of neutrophil and platelet recovery after chemotherapy, and expansion of stem cells outside the body.
Stem Cell Transplantation
Ongoing research in stem cell transplantation includes the identification of alternative allogeneic (non-identical human) donors including unrelated umbilical cord blood, unrelated adult bone marrow, mismatched family member, new methods to purify autologous (patient’s own) stem cells, and reduction in complications of graft-versus-host disease.
Molecular Oncology is the study of cancer from a molecular level and is often seen as the core of a basic understanding of cancer and its cure. This research involves the investigation of the genes and mechanisms associated with the initiation, development, and control of childhood leukemia and lymphomas.
The Pediatric Cancer Research Foundation (PCRF) helps fund lifesaving pediatric cancer research with the help of people like you. We support current and emerging researchers in laboratories across the country focusing on new and exciting research ideas that provide hope for a future of improved cancer treatment and reduced childhood cancer rates. We have already come so far, but there is more work to do and you can help us do it.
Some people say that children make up 10% of our cancer population, but they are 100% of our future! ~ Dr. Alex Huang, Case Western