PCRF - Funding Hope

Standing Vigil Until a Cure is Found

Your Gift Powers HOPE

The Pediatric Cancer Research Foundation identifies and invests in leading-edge research that demonstrates the best hope for curing childhood cancer. PCRF invites you to walk with us as we vigorously pursue eliminating childhood cancer through research.

An average of 43 children and adolescents are diagnosed with cancer every day in the United States (almost 16,000 annually) and that number is dramatically compounded when we look worldwide: nearly 250,000 new cases of cancer affect children annually, or 700 new children affected every day around the globe (The Lancet Oncology. 2013; 14(3): e95-e103). As evidenced by these numbers, pediatric cancer is not rare – in fact, it remains the number one disease killer of all children. More children die from cancer than pediatric AIDS, asthma, diabetes, cystic fibrosis, and congenital anomalies combined (Cancer in Children and Adolescents). Time will not stand still as we search for a cure, which means we must work quickly, strategically, diligently, and in collaboration to combat childhood cancer. We thank you for your partnership and contributions that help give hope to children and families.

Founded in 1982 by physicians, parents, and community leaders, Pediatric Cancer Research Foundation (PCRF) has raised over $51 Million for cancer research since its inception. This represents the ongoing hard work of physicians, researchers, volunteers, staff, and community partners dedicated to our future generation’s health—our children. Over the last 40 years, we have seen drastic improvements – overall survival rates for childhood cancer have risen from 10% to almost 85%. Because of research, the cancer death rate has dropped more dramatically for children than for any other age group. However, there are still childhood cancers that have not had the same results – rare and aggressive cancers continue to devastate families and rob children of their childhoods.

Together, we’ve made considerable strides in the treatment, care, and prevention of childhood cancers. However, as we look back and celebrate our progress, we also look forward – knowing there is more work to be done. PCRF is a pioneer in eliminating childhood cancer through our ability to identify and fund cutting-edge research. We exclusively target funds toward emerging and breakthrough opportunities.

Your partnership with PCRF powers hopeful advancements: Hope for a cure, hope for aggressive treatments that attack cancer cells but leave the healthy cells, hope for long-term quality of life through safer therapies to fight cancer. Hope for new research, new protocols, new interventions.

Decades of Progress, Success, Hope


  • The Bone Marrow Transplant Laboratory opens at CHOC.
  • The processing and purging of bone marrow is made possible.
  • Autologous and allogeneic bone marrow transplantations are successfully performed.  


  • Umbilical cord blood transplant is performed at CHOC.


  • First ex-vivo cord blood transplant performed at Georgetown University Lombardi Cancer Center.


  • The PCRF Consortium expands its role with institutions across the US.


  • The PCRF Clinical Consortium registers it’s 1,000th patient.


  • PCRF celebrates 30 years of funding cancer research.


  • PCRF funds emerging investigator grant category.


  • PCRF presented it’s 5th International Symposium on Childhood Adolescent & Young Adult Non-Hodgkin Lymphoma.


  • Reached a record high of funding 31 leading institutions since our inception.


  • Introduced the Survivor’s Scholarship Program.


  • Funded a record high of $2.1 million in new annual grants.

What We Know About Childhood Cancer


Pediatric cancer is a growing problem worldwide. A child or adolescent is diagnosed with cancer every two minutes. In the United States, cancer is the leading cause of death by disease in children past infancy. The facts and information available challenge everyone to become involved with PCRF’s mission to identify and invest in leading edge research that demonstrates the best hope for a cure of childhood cancer. Share this information with others and encourage them to join the fight.

Children 0-14 years diagnosed with cancer in the U.S. each year
Adolescents age 15-19 diagnosed with cancer in the U.S. each year​
Youth under 19 diagnosed with cancer each year worldwide​
Youth under 19 diagnosed with cancer each year worldwide​

What PCRF has Accomplished

$ 0 m
Raised for Pediatric Cancer Research​
Active Grants for Pediatric Cancer Research
0 +
Research Institutions Funded

Your Support Powers Results

Throughout our history of supporting pediatric cancers, we have maintained a stable foundation financially. This year we attained a Platinum rating from GuideStar. As a donor, you can have confidence in PCRF’s ability to fund the best researchers in the world, with the utmost attention to financial efficacy and transparency.

The Pediatric Cancer Research Foundation has been sustained for the last 40 years, thanks to the caring investment of individuals, organizations, and businesses like you!
Your trust over the years is valued and put to excellent use advancing effective life-saving treatments for children diagnosed with malignant disease.

PCRF, located in Irvine, California, currently funds 13 institutions across the country. Cancer knows no boundaries, and neither do we. We will stand vigil until a cure is found.

PCRF is a GuideStar Platinum Participant

The People that Make it Happen

Change a Life Today

Children make up 10% of our cancer population, but they are 100% of our future! ~ Dr. Alex Huang, Case Western