Project Description

Dr. Ting Tao
Emerging Research Grant
– Neuroblastoma

Dana-Farber Cancer Institute

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Dr. Tao’s work uses zebrafish to study the molecular basis of neuroblastoma and develop new treatments for this devastating disease. Zebrafish are used to study cancer because they share many genes with humans and can develop almost any tumor that we can. Their translucent skin allows us to watch as tumors form and grow and observe whether the tumors respond to new experimental treatments.
With a grant from the Pediatric Cancer Research Foundation, Dr. Ting Tao of Dana-Farber Cancer Institute is working to understand the mechanisms of how cancerous neuroblastoma cells can turn into noncancerous ganglioneuroma cells. I will use zebrafish models to investigate novel mechanisms that indicate how activation of the AKT kinase inhibits malignant transformation of MYCN-induced neuroblastoma. These studies will likely lead to a novel pathway of how neuroblastoma develops, which will reveal new targets for improved therapy of high-risk neuroblastoma.

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