While cancer in children is considered rare, it is the leading cause of death by disease among children in the USA. In the last 20 years, only four new drugs have been approved specifically for children. Some would say this is a start, but these children deserve more momentum, and that is contingent on investments. In 2021 our open grant cycle gleaned 42 letters of request. Only 7 were funded, leaving 35 research projects unfunded.